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A subgroup of individuals with autism may show evidence of mitochondrial stress or altered energy metabolism

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Unlike traditional inhibitors, which merely block protein activity, PROTACs remove the protein entirely, conferring several distinct advantages: (1) Complete Protein Removal: Eliminates the target protein entirely, preventing compensatory mechanisms and overcoming resistance associated with target overexpression

Therefore, developing therapeutic techniques (Table 1) to promote endogenous neurogenesis to repair neurological deficits after neonatal HIBD is an urgent priority