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Using SUMO1 truncations Liang et al

Doboquinone reacts with cysteine to form cysteinyldopa, which further polymerizes to produce brownish melanin (Wakamatsu et al., 2017)

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They showed that left cVNS started during late ischemia, but not at reperfusion, still retained beneficial effects on electrical stability, infarct size (59% reduction), cardiac function, inflammatory biomarkers, ROS production and phosphorylated Cx43 levels, providing an important translational message