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Data availability The source data for the findings of this study are available from the corresponding author upon reasonable request

Nootropics act on signaling, meaning the levels and balance of neurotransmitters and the excitability and gain of a network

As the purpose of the intra-luminal guidance is to direct the axon growth cone across the gap, once the first axons have bridged the gap, the presence of intraluminal guidance is no longer necessary and its degradation provides more space to fill by the native ECM [51]

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