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Fig.2 ADCs containing a disulfide linker

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IGF-1 regulation of oxidative stress in Alzheimers disease (AD) and related dementias Moreover, intriguing parallels have emerged between OS and the accumulation of lipid peroxidation products, along with altered expression patterns of insulin/IGF signaling and receptors in postmortem human brain tissue from cases of frontotemporal lobe dementia [42]