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Fibrinogen-Mimetic Nanoplatforms: Platelet-activatable nanoparticles (e.g., RGD-Chi@tPA) enhance thrombus targeting and tissue plasminogen activator penetration for efficient thrombolysis [110](Figure 6)

Notably, the contribution of the Gardos channels to eryptosis-associated cell shrinkage is supported by the fact that their inhibitors charybdotoxin and clotrimazole can avert cell shrinkage [78, 79]

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The CP is initiated by C1q binding to antigen-antibody complexes, thereby inducing a cascade via C2 and C4 cleavage, leading to the production of CP C3 convertase (C4b2b)

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