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Within the ER, newly synthesised proteins are oxidised by PDI, which in turn are again re-oxidised by ER oxidoreductase 1 (ERO1) in a reaction that generates H 2 O 2 72 , reviewed by 76

(141) used 14 to 16-week-old male C57BL/6NTac mice to study the effects of 4 months of IF (16 h of daily fasting) on inflammasome-mediated cell death in the cerebellum after chronic cerebral hypoperfusion (CCH)