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In response to hepatocyte injury, Kupffer cells release CCL2, facilitating monocyte recruitment and migration to the liver, where they differentiate into pro-inflammatory macrophages [58]

Liver regeneration is severely impaired when macrophages are depleted in response to acute liver injury, such as PHx, acetaminophen overdose, acute carbon tetrachloride (CCl 4 ) or chronic liver injury

This process is common and highly prevalent in psychiatric disorders, such as depression and autism

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