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CD38 CD38 is a multifunctional enzyme involved in NAD + metabolism and intracellular signaling (Xie et al

JNCI J Natl Cancer Institute

Cytotoxic CTLs and NK cells identify tumor cells via recognition of MHC-1 expressed on tumor cell surface, and HIF-1 downregulates the MHC-1 expressed on tumor cells, preventing immunologic attack by CTLs and NK cells [34,37,38,81]

Galili and coworkers described anti-Gal antibodies as representing natural antibodies existing in the plasma of all humans at high concentrations of up to 1% of total IgG (Galili et al., 1986)