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30 years of NF-kappaB: A blossoming of relevance to human pathobiology

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About 65 percent of people actually report positive things such as feeling lighter, being less inflamed, being less reactive to a variety of substances, and having more energy, within the first week or so

doi: 10.1182/blood.V92.7.2495 127 TakeiHArakiAWatanabeHIchinoseASendoF

However, many of these hits also play critical roles in normal immune cell function, raising concerns about potential off-target effects and immune toxicity