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Yes, especially with acetaminophen, NSAIDs, and chemotherapy drugs

This would also indicate potential unwanted side effects of inhibition of UBE4B, including increased risk of adverse drug reactions

doi: 10.3390/diagnostics13122038 165

Pollizzi KN, Patel CH, Sun IH, Oh MH, Waickman AT, Wen J, et al

While 12 weeks of bright light exposure did not produce measurable improvements in sleep quality, glucose metabolism, or inflammatory markers, it significantly altered clock gene expression in peripheral blood mononuclear cells (PBMCs, specifically decreasing REV-ERB levels and increasing the REV-ERB/BMAL1 ratio)