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Drug delivery of macromolecules can also be afforded via this transport route, which relies on the electrostatic interactions between the surface of positively charged NPs (functionalized for instance with positive polymers, cationic lipids, albumin) and negative charges naturally present on endothelial plasma membrane (due to the presence of anionic proteoglycans) of the BBB (Poon and Garipy, 2007

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They're often taken as injections for injury recovery, muscle growth, fat loss, athletic performance, metabolism and so on

reported only one case of IgA nephropathy out of 35 patients who underwent renal biopsy after developing nephrotic syndrome due to chronic mercury intoxication [32]