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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

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doi: 10.1017/S0029665121001956

Pharmaceutical companies walk away from promising preclinical compounds all the time when the risk-benefit calculus doesn't add up

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