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Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells

Efruxifermin (formerly AKR-001, AMG 876), the only other FGF21 analog studied in a clinical trial of biopsy-confirmed NASH patients, is a 92 kDa Fc-FGF21fusion protein with a 33.5 day half-life (based on intact C-terminal domain of the FGF21 moiety), which is substantially extended relative to the FGF21 analogs described above

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Replenishing glutathione levels through oral liposomal and IV administration accelerates recovery, particularly in patients with genetic variations that impair glutathione production

As with any compounded medication, administration should be performed by qualified personnel familiar with sterile injection techniques and patient monitoring