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In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (34, 48)

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For example, p53 depletion can enhance cell proliferation and survival, disrupt apoptosis and increase genomic instability by altering the expression of REDD1, an mTOR suppressor