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The Deseq2 package in R was employed for the calculation of log2 fold changes in transcript expression

The frozen samples were then ground into a fine powder using a tissue grinder (Shanghai Jingxin, China)

Modifications have been tested at the internucleotide phosphodiester bridge (e.g., using phosphorothioate, methylphosphonate or phosphoramidate linkages), at the nucleotide base (e.g., 5-propynyl-pyrimidines), or at the sugar (e.g., 2-modified sugars) (Uhlmann E., et al

Heres what a typical clinical response looks like over a 12-week cycle

The use of skeletal extension torque in reversing Dupuytren contractures of the proximal interphalangeal joint