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Mendelian randomization has confirmed a significant association between PM2.5 exposure and increased genetic susceptibility to UC [240], Immigrant studies also indicate that individuals migrating from low-incidence to high-incidence areas have an elevated risk of IBD [241, 242], while high birth order ( 3), due to early exposure to infections, is associated with a reduced risk of IBD [243], These macro-epidemiological findings underscore the importance of the synergistic role of environmental changes and genetic background

Notably, numerous studies have demonstrated that DMF alleviates cognitive and motor dysfunction by mitigating neurodegeneration, oxidative stress, and neuroinflammation in rodent models of Parkinsons disease (PD) [56], AD [57, 58], frontotemporal dementia [59], traumatic brain injury (TBI) [60], and ischemia [61]

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