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Cuproptosis and ferroptosis share some characteristics, such as increased density of the bilayer membrane structure, lethal ROS production due to the Fenton reaction and mitochondrion-regulated cell death

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Building on the modulation of neurotransmitter systems, another crucial dimension of neuroprotection involves sustaining the cellular environment that allows neurons to survive, adapt, and thrive

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We were therefore more confident that the new P4 1 2 1 2 crystal system would be better suited than the previous system for the identification and confirmation of TRF1:TIN2 PPI inhibitors