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Connective tissue then replaces degraded tissue in a process called fibroplasia or fibrosis

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Potential therapeutic strategies include drugs that remove iron from mitochondria (iron chelation) or drugs that neutralize free radicals (antioxidants, such as coenzyme Q10)

Cell adhesion molecules and cytokines: After the occurrence of an ischemic stroke, there is growing evidence of post-reperfusion inflammation during which leukocytes are recruited with the help of adhesion molecules from the selectin family, integrins (1 and 2), and intercellular adhesion molecule-1 (ICAM-1) [113,119]

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