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This enzyme converts L-arginine into nitric oxide and L-citrulline

Liquid chromatography-tandem mass spectrometry was employed to quantify plasma TMAO, choline and their related metabolites, encompassing TMA, l-carnitine, betaine and dimethylglycine (DMG), which are betaine-related metabolites (Reference Wiedeman, Barr and Green14)

MATERIALS AND METHODS We performed a systematic review of the literature, using Ovid MEDLINE databases and reference lists of retrieved articles

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CIT functions as a precursor to L-arginine, thereby facilitating the synthesis of NO through the activation of eNOS, which in turn enhances endothelial functionality, vasodilation, and the perfusion of skeletal muscle (11)