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This extraordinary potency difference stems from Dihexas mechanism as an HGF mimetic binding to c-Met receptors, which triggers intracellular signaling cascades distinct from BDNFs TrkB receptor pathway

Then, the medium was changed to fresh DMEM containing DCFH-DA (10 M) and Hoechst 33342 for ROS analysis and nuclei stain

Mol Carcinog 55(5):473485 Siebert A, Desai V, Chandrasekaran K, Fiskum G, Jafri MS (2009) Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures