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Impaired membrane stability promotes inflammatory factors and metabolites into the lymphatic and circulatory systems, and participates in the development of COPD through the gutlung axis

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HIF-1, the warburg effect, and macrophage/microglia polarization potential role in COVID-19 pathogenesis

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The deprivation of glutamine leads to a substantial reduction in the levels of M2-specific marker genes (Arg1, Interferon Regulatory Factor 4 [IRF4], Kruppel-Like Factor 4 [KLF4], Chemokine [C-C motif] Ligand 22 [CCL22], and IL4), as well as reduced transcription of TCA cycle components, thereby decreasing the cycles activity, while increasing the expression of M1-sensitive marker genes, including IL1, TNF, IL6, and IL12, suggesting a close association between glutamine metabolism and macrophage polarization (Jha et al