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It was early reported that HIF-1 is upregulated through SUMO1 modification at K391 and K477 residues, which may stabilize HIF-1 and enhance its transcriptional activity [185]

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Despite the absence of solid components and despite the absence of vascularity on color Doppler, the size and the multi-loculated aspect of this lesion are suspicious for a cystic neoplasm and warant further evaluation