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Later, another study showed that a Parthenolide (PTL)-derived drug DMOCPTL directly bound to the GPX4 active site (selenocysteine 46), and led to GPX4 ubiquitination in triple-negative breast cancer cells ( Discovering the E3 ligase is also very important for understanding the regulatory mechanisms of protein ubiquitination

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This was exactly what a hyperbaric chamber was capable of doing, and soon chambers were made available at bridge construction sites, and later on at dive meccas all over the world

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