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Amino acid signatures in relation to polycystic ovary syndrome and increased risk of different metabolic disturbances

Nature 455 , 1198-U1123

Excitotoxicity Neuronal dysfunction and death caused by the accumulation of excess neurotransmitters, primarily glutamate, in synapses

Possible Mild Side Effects: Stomach upset or nausea if taken on an empty stomach Mild headaches or cramps due to dehydration Slight restlessness if taken too late in the evening Important Safety Tips: Avoid taking it late at night to prevent sleep disruption Stay hydrated throughout the day to help fat transport and reduce cramps Do not combine it with caffeine-heavy supplements unless approved by a health professional By following these guidelines and taking it consistently at the best time to take L-carnitine, you can enjoy its full benefits safely and effectively

Additionally, downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a crucial regulator of the cellular antioxidant response, compromises the hepatocytes first-line defence against oxidative injury [50, 51]