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In addition, the produced 2-HG reduces the tumor pathogenesis by downregulating HIF-1 expression [23] and improves immune response by epigenetically silencing PD-L1 (programmed cell death ligand 1) expression on cancer cells [24]

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Dermal Filler Aftercare: What to Expect For the first 24 to 48 hours following treatment, patients are advised to: Avoid strenuous physical exercise Refrain from alcohol consumption Avoid applying excessive pressure to the treated area Sleep with the head slightly elevated Mild swelling and occasional bruising are a normal part of the healing process and typically resolve within a few days