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Those who are allergic to Zepbound or Tirzepatide Those with type 1 diabetes Those with a family/personal history of thyroid cancer or thyroid problems People with a history of severe gastrointestinal disease Those with multiple endocrine neoplasia syndrome type 2 (MEN 2) People with disease of the pancreas (pancreatitis) Those with kidney disease Those who are pregnant or planning to become pregnant Those who are breastfeeding Speak with your medical provider before starting Zepbound if you have any of the above conditions or potential concerns

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You can find additional information about the risks of FDA-approved medications that contain semaglutide here

Vegans and Vegetarians : Since B12 is primarily found in animal products, those following a plant-based diet are often at risk of deficiency

We have also assessed the quality of stratified results reporting in clinical trials registered at ClinicalTrials.gov with at least one site in the United States, with annual reporting by year of primary completion shown in Figures B-10a and B-10b (stratified by funder as reported by ClinicalTrials.gov, and the difference indicated between all phases and just Phase 3 [commonly registrational] trials)