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216 A prospective study including 2944 healthy medical staff in the epidemic areas from Taihe Hospital in Shiyan City, Hubei, China, showed that the incidence rate of COVID-19 was zero in both the low-risk group ( n = 2415) and the high-risk group ( n = 529) after treatment with recombinant IFN- nose drops for 30 days (NCT04320238), 217 indicating the preventive roles of recombinant IFN- in COVID-19

Besides confirming these results, another study run in rats (52-53) showed a significant decrease in pro-angiogenic factors such as VEGF at both serum and peritoneal fluid levels, but also a significant decrease in pro-inflammatory molecules such as MCP-1 in the peritoneal fluid and at the serum level

Injections are given subcutaneously abdomen, thigh, or upper arm are best

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Curr Opin Gastroenterol (2007) 23:37983.10.1097/MOG.0b013e32816aa392 45 StroberWFussIJ