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Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

S7 and S8AD)

The importance of betaine or its precursor choline in promoting Hcy remethylation is also supported by the observation that treatment of patients with metabolic syndrome or diabetes mellitus with fibrates resulted in abnormal renal excretion of betaine and a rise in plasma total Hcy (tHcy) (50)