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doi: 10.1182/blood-2009-12-257345 88 DerenziniEYounesA

Multiple mechanisms are responsible for the anemia, but the main mechanisms are decreased RBC production due to suppression of erythropoiesis, reduced iron availability, and decreased RBC lifespan (extravascular hemolysis)

Histone acetyl transferase (HATs) family, which catalyzes the transfer of the acetyl group from acetyl-CoA to histones, including P300/CBP, MOF, GCN5 and TIP60 are also reported catalyzes the transfer of lactate groups from lactate-CoA to histones in different disease and disease states [16, 88, 165, 181, 182]