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High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans

However, in July 2018, it was reported that an error had occurred in 2016 in which two lots of the same medicines were dispensed and supplied to the same patient, Richard Lee, who subsequently died

Metformin improves mitochondrial respiratory activity through activation of AMPK

Front Behav Neurosci (2018) 12:266

When the type of diabetes is uncertain or atypical, additional investigations including C-peptide levels and diabetes-specific autoantibodies (e.g., GAD antibodies) may be arranged to help clarify the diagnosis