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A recent report with amylin receptor structures clearly showed that the N-terminal part of amylin interacted with the TM domain of the amylin receptor and that the C-terminal part of amylin interacts with amylin receptor ECD [15]

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This phenomenon was also observed by immunoblotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR) in several models that we had freshly frozen liver tissues (Fig