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Any disruption to BBB integrity can lead to altered cerebral function, contributing to different neurological diseases, including cognitive dysfunction (Ronaldson and Davis, 2020

Fifty years of advances in bile acid synthesis and metabolism

The results demonstrated that BV2-metformin-loaded PLGA treatment reduced TNF- and GFAP expression, confirming suppression of neuroinflammation, while p62 levels were increased, indicating enhanced autophagy

Pasternak, A

Additionally, these molecules interfere with various signaling pathways activated by oxidative stress, preventing the excessive production of reactive oxygen species [4,23]