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As for folic acid itself, The Migraine Institute cites a study published in The Journal of Headache and Pain examining folic acids potential in treating migraines

If you experience symptoms such as unusual tingling or numbness in hands or feet, difficulty walking, visual disturbances, or severe fatigue during pregnancy, seek prompt medical assessment as these may indicate B12 deficiency requiring treatment

Early studies in cats using various administration routes (IV, intra-arterial, intrarenal) and dosages have raised minimal safety concerns, however efficacy results were mixed and follow-up durations were short (23 months)

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