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Specifically, CLP-induced systemic inflammation may activate microglia to secrete pro-inflammatory mediators, which suppress the Nrf2/HO-1/GPX4 redox axis, triggering mitochondrial dysfunction and oxidative stress

doi: 10.3390/ijms241813784

doi: 10.1002/pros.70038 186 Gonzalez CaoMRodnJKarachaliouNSantarpiaMVivancosARosellR

[DOI] [PMC free article] [PubMed] [Google Scholar] d'Emmanuele di Villa Bianca R, Mitidieri E, Fusco F, Russo A, Pagliara V, Tramontano T et al (2016)