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(Lee et al., 2021) conducted comprehensive analyses utilizing datasets such as the Korean Association Resource (KARE), Health Examinees (HEXA), and Cardiovascular Disease Association Study (CAVAS), employing both one-sample Mendelian Randomization (MR) and two-sample MR methods

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This receptor upregulation combines with BPC-157's activation of the Src-Caveolin-1-eNOS signaling cascade, which increases nitric oxide production by 1.35-fold and proves essential for the peptide's pro-migratory effects on endothelial cells