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While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of hydrocodone bitartrate and acetaminophen tablets, the risk is greatest during the initiation of therapy or following a dosage increase

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Supplementary Figure 7 Correction for diverging offsets in the titration analysis To eliminate the effect of different DNA methylation levels at the extreme points of the titration series, we proceeded in three steps: First, for each titration series and each genomic region we determined the difference between the median of the consensus corridors for the 0% and 100% titration ratios

States of physiologic stress, including those resulting from the treatment of malignant disease, are characterized by a relative deficiency of glutamine

and (4) ophthalmologic history to flag intracranial-pressure-related symptoms