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With a high dietary supply of methionine-rich animal proteins, an increase in tissue concentrations of SAM occurs, and 70% of homocysteine is catabolized by CBS through the transsulfuration pathway (Fig

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Novel aspects of toxicity mechanisms of dioxins and related compounds

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Efficacy of serine/glycine conversion inhibitor sertraline with radiotherapy was investigated by proliferation, clonogenic and spheroid assays, and in vivo using a serine/glycine dependent NSCLC mouse model by assessment of tumor growth, metabolite and cytokine levels, and immune signatures