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Briefly, the 8-OH-dG monoclonal antibody binds competitively to the pre-coated 8-OH-dG as well as in the cell homogenate

10.1016/j.heliyon.2024.e41068 69 RosenfieldR

This could be because oxidative stress causes an ovarian inflammatory and apoptotic microenvironment, which in turn inhibits and/or shuts off the ovarian steroidogenesis pathway 57,58

AMPK-related signalling pathway Reports have confirmed that adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) plays a crucial role in regulating cellular energy metabolism homeostasis