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Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial

The underlying mechanisms initiating the stimulation of carbohydrate catabolism processes are still not perfectly understood, although AMPK, the energy stress sensor kinase, could play a determinant role in this phenomenon [138]

In research settings, this peptide is commonly utilized for studying NMDA-receptor-associated neuromodulation, hypothalamic-pituitary-adrenal axis dynamics, and related biochemical mechanisms

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