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Multiomics Insights into the Mechanism and Enhanced Efficacy of Tumor Treating Fields (TTFields) Therapy in Glioblastoma

NPJ Aging 9 , 1 (2023)

HELLP is an acronym for a syndrome seen in pregnant women that causes hemolytic anemia (blood cells rupture), elevated liver enzymes, and low platelets

Mechanistically, this effect was mediated by blocking the Akt/Forkhead box protein O1 (FoxO1) interaction, which inhibited the transcriptional regulation of apoptosis and, in turn, reduced age-related ovarian oxidative stress injury