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The specificity of AIF and AIF3 RNA probes was verified in human cell line MDA-MB-231 expressing endogenous AIF or CRISPR/Cas9-produced AIF3 (Supplementary Fig

OCA treatment ameliorated high-fat diet (HFD)-induced dysplasia, potentially by reducing deleterious secondary BAs (e.g., DCA, TDCA), decreasing microbial bile salt hydrolase (BSH) expression, and favorably reshaping the tumors immune landscape (128), thereby potentially reversing an immunosuppressive TIME

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Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS

Fernandez-Barrena: Nothing to Disclose, Matas vila: Nothing to Disclose, Carolina Armengol: Nothing to Disclose, M Luz Martnez-Chantar: Nothing to Disclose 2498 LIVER LYMPHATIC CHANGES IN BILIARY ATRESIA FROM DIAGNOSIS TO TRANSPLANT Alyssa Goldberg 1 William Hollenbach 2 Cara Mack 3 Beth Tamburini 4 , 1 Children's Hospital Colorado, 2 University of Colorado at Denver, 3 Medical College of Wisconsin, 4 University of Colorado Background: The liver lymphatic system supports organ health by draining interstitial fluid and immune cells to the lymph node