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Karlin, 2011)

Methionine intake, folate levels, and vitamin B12 availability all influence the cycle's capacity to support methylation and homocysteine clearance

One commenter stated that accounting for improper payments in benchmarks is a welcome change and significant improvement. Response: We appreciate commenters' support for our proposal to establish an adjustment to Shared Savings Program benchmark calculations to account for the impact of identified improper payments for use in reaching an initial determination of financial performance for a performance year, in certain cases