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The convenience and ease of administration make nasal sprays a valuable tool for protocols requiring frequent dosing, enhancing compliance and simplifying the application process for both researchers and subjects alike

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Levels of pro-inflammatory cytokines, such as IL-1, IL-6, IL-8, and IL-12p40, have been shown to be increased in the plasma of ASD patients ( Lactobacillus sakei , Lactobacillus reuteri , Lactobacillus paracasei , Lactobacillus plantarum , Lactobacillus acidophilus , Lactobacillus salivarius and Bifidobacterium breve , modulate or inhibit the production of pro-inflammatory cytokines IL-8, TNF-, and IFN- and increase the anti-inflammatory cytokine IL-10 (Thomas and Versalovic, 2010