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From these enzymes, glutathione peroxidase, catalase, and superoxide dismutase together form a common system aimed at protecting the cell from peroxidant molecules [38]

In DM, hyperglycemia-induced ROS production worsens beta-cell failure and insulin resistance through pathways such as the AGE-RAGE signaling, protein kinase C (PKC) activation, and the polyol pathway

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The debate over oral glutathione's efficacy was largely settled by a landmark 6-month randomized, double-blind, placebo-controlled trial conducted at Penn State University

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