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Much of this benefit is thought to be because of milk thistles ability to increase glutathione while reducing lipid peroxidation

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Glutathione levels are also found to be decreased in central nervous system disorders (such as Alzheimer disease and Parkinson disease), autism, cardiovascular system disorders (atherosclerosis), peripheral vascular disorders, diabetes and its complications, liver disease, acquired immunodeficiency syndrome/human immunodeficiency virus, and chronic obstructive pulmonary diseases

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BIM, PUMA, and tBID exhibit broad-spectrum binding capabilities to all anti-apoptotic proteins, thereby neutralizing their activities and initiating apoptosis