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ACMSD: a novel target for modulating NAD(+) homeostasis

Compared with ADCs, PDCs exhibit better tumor penetration because of their small molecular weight, lower systemic exposure (owing to rapid clearance from the body), lower risk of immunogenicity and liver damage, and easier and cheaper production methods

The 1993 New England Journal of Medicine study on tretinoin showed an 80% increase in Type I collagen formation in photodamaged skin after 10 to 12 months of treatment

KPV also reduces the expression of swelling enzymes including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), which produce swelling mediators prostaglandins and nitric oxide respectively