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In HNSCC, HGF is majorly secreted via tumor-associated fibroblasts (TAFs) in the tumor microenvironment [80, 81]

The downstream cascades of HGF/c-Met include JAK/STAT3, PI3K/Akt/NF-B, and Ras/Raf pathways, affecting cell proliferation, growth, and survival

BPC-157's angiogenic properties address this directly, while TB-500 promotes the cell migration needed for structural repair