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Inhibits apoptosis in various cell types including retinal neurons

Alterations in regulatory components of NOX2 results in generation of phagocytic oxidative stress and phagocytic burst to eliminate enclosed pathogen [58]

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There are two types of amplifiers which have showed promising results in pre-clinical and clinical trials, PTI-428 and PTI-CH (Proteostasis Therapeutics Inc., USA), even though they are not yet available on the market (Kym et al., 2018