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FIGURE 1 Together, these elementsmechanism-based classification, PK/PD and biomarker emphasis, explicit clinical and immunotherapy safety benchmarking, multi-omics-enabled translational pipeline, and One Health integrationdifferentiate this article from prior OSC reviews and provide a roadmap from mechanistic promise to clinically and ecologically responsible dual-action application

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and third, drugs that directly eliminate lipid free radicals to inhibit ferroptosis (Table 2) (Liang et al., 2023)