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The earliest study was a phase 3 REGARD trial (73) conducted in 2009, which involved 355 patients with GC or gastroesophageal junction adenocarcinoma who underwent first-line platinum- or fluoropyrimidine-containing chemotherapy

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10.1128/JVI.77.5.2936-2945.2003 77 MauclerC.PernotP.VasylievaN.PollegioniL.MarinescoS